Inhalation Product testing and characterisation
Inhalation product characterisation requires both deep product understanding and the right analytical capabilities. At MVIC, we offer high-quality, customised inhaler testing tailored to your specific needs. With extensive experience in dry powder inhaler testing, we perform both standardised and client-adapted methods to ensure reliable results. Using advanced tools such as NGI, ACI, and laser diffraction, we deliver precise aerosol characterisation to support every stage of development.
Our Capabilities and Techniques
Aerodynamic particle size distribution (APSD) is along with delivered dose crucial to fully understand the impact of a candidate aerosol. MVIC is a full-service partner with a unique ability to assist in product characterisation of inhaled pharmaceuticals. We use in silico modelling of lung deposition and predict PK outcomes based on in vitro data.
Impactor Based Testing and Lung Deposition
As part of our inhalation product characterisation, we perform inhaler testing to predict lung deposition based on particle size. Using NGI, ACI, and MSLI, we assess aerosol performance in both standard and anatomically realistic throat models. Our dry powder inhaler testing includes realistic inhalation profiles to support in vitro predictions of in vivo outcomes.
Spray Pattern and Plume Geometry
Using the Oxford Lasers Envision system, we perform high-resolution inhaler testing to analyse spray pattern and plume geometry. The open setup allows flexible distances and captures data at up to 500 Hz. The system supports inhaler-specific housings and "push-through" airflow triggering, making it ideal for realistic inhalation product characterisation.
Delivered Dose Testing
Consistent dosing is essential in inhalation product characterisation. At MVIC, we use both pharmacopeia-standard DUSA setups, and faster, less labour-intensive methods for dry powder inhaler testing. We also develop customised and automated dose collection systems in collaboration with our clients, ensuring reliable inhaler testing tailored to each project.
Droplet and Particle Size Distribution
MVIC offers a range of methods for inhalation product characterisation, including both liquid and dry powder inhaler testing. Capabilities include laser diffraction, aerodynamic particle sizing with impactor inlets for screening, and both open and closed inhalation cells to measure PSD across product types.
FAQs
Here you’ll find answers to some of the most common questions we receive. Still wondering about something? Feel free to get in touch – we’re happy to tell you more!